SAP18 blocking peptide product blogThe SAP18 sap18 (Catalog #MBS9221295) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The SAP18 sap18 product has the following accession number(s) (GI #6831678) (NCBI Accession #O00422.1) (Uniprot Accession #O00422). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
Cellular Location: Nucleus. Cytoplasm. Nucleus speckle. Note: Shuttles between the nucleus and the cytoplasm. Colocalizes with ACIN1 and SRSF2 in nuclear speckles. Tissue Location: Ubiquitous. Bone, Brain, Embryonic Tissue, Liver, Mouth, Muscle, Ovary, Salivary Gland, Testis tissues are correlated with this protein. The following patways have been known to be associated with this gene. SAP18 also interacts with the following gene(s): ACIN1, GLI1, HDAC1, MAGOH, RNPS1, SAP30, SIN3A, SUFU. Fatty Liver, Liver Diseases, Non-alcoholic Fatty Liver Disease are some of the diseases may be linked to SAP18 Antibody (Center) Blocking Peptide.