Pdk4 blocking peptide product blogThe Pdk4 pdk4 (Catalog #MBS9221149) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The Pdk4 pdk4 product has the following accession number(s) (GI #12585303) (NCBI Accession #O70571.1) (Uniprot Accession #O70571). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
Cellular Location: Mitochondrion matrix. Pdk4 also interacts with the following gene(s): Pdha1, Pdhx. Atrophy, Cardiovascular Diseases, Fatty Liver, Heart Diseases, Hyperglycemia, Hypertrophy, Inflammation, Liver Diseases, Necrosis, Weight Loss are some of the diseases may be linked to Mouse Pdk4 Antibody (N-term) Blocking Peptide. Artery, Bone, Brain, Embryonic Tissue, Heart, Kidney, Lung, Muscle, Pancreas, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene.