LEPR blocking peptide product blogThe LEPR lepr (Catalog #MBS9225917) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The LEPR lepr product has the following accession number(s) (GI #40254464) (NCBI Accession #NP_002294) (Uniprot Accession #P48357). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: Isoform An is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary Low level in lung and kidney. Isoform B is highly expressed in hypothalamus. The following patways have been known to be associated with this gene. Diabetes Mellitus, Diabetes Mellitus, Type 2, Drug-Related Side Effects and Adverse Reactions, Immunologic Deficiency Syndromes, Inflammation, Insulin Resistance, Liver Diseases, Necrosis, Obesity, Overweight are some of the diseases may be linked to Leptin Receptor (LEPR) Antibody (N-term) Blocking peptide. LEPR also interacts with the following gene(s): JAK1, JAK2, LEP, SOCS3, STAT3. Adipose Tissue, Blood, Bone, Brain, Connective Tissue, Eye, Liver, Muscle, Nerve, Skin tissues are correlated with this protein.