CYP3A4 blocking peptide product blogThe CYP3A4 cyp3a4 (Catalog #MBS9227253) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CYP3A4 cyp3a4 product has the following accession number(s) (GI #116241312) (NCBI Accession #P08684.4) (Uniprot Accession #P08684). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1\'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide.
Cellular Location: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Tissue Location: Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056) According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level). The following patways have been known to be associated with this gene. Adrenal Gland, Brain, Connective Tissue, Intestine, Kidney, Liver, Mammary Gland, Mouth, Muscle, Stomach tissues are correlated with this protein. CYP3A4 also interacts with the following gene(s): FMO1, NR1I2, NR1I3, UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7. Breast Neoplasms, Drug-Related Side Effects and Adverse Reactions, Heart Diseases, Hypertension, Inflammation, Kidney Diseases, Liver Diseases, Liver Neoplasms, Nervous System Diseases, Pain are some of the diseases may be linked to CYP3A4 Antibody (Center) Blocking Peptide.