COMP blocking peptide product blogThe COMP comp (Catalog #MBS9226417) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The COMP comp product has the following accession number(s) (GI #209572601) (NCBI Accession #P49747.2) (Uniprot Accession #P49747). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
Cellular Location: Secreted, extracellular space, extracellular matrix. Tissue Location: Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. COMP also interacts with the following gene(s): ACAN, ADAMTS12, CD36, CD47, COL2A1, ITGB1, MATN1, MATN3, MATN4. Bone, Brain, Connective Tissue, Embryonic Tissue, Heart, Intestine, Liver, Ovary, Skin, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Disease Models, Animal, Fatty Liver, Hypertension, Immune System Diseases, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Nerve Degeneration, Weight Loss are some of the diseases may be linked to COMP Antibody (Center) Blocking Peptide.