anti-RARB antibody product blogThe RARB rarb (Catalog #MBS500014) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Retinoic Acid Receptor, beta-Isotype reacts with Human, rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Retinoic Acid Receptor, beta-Isotype can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Quality Control: Western blots performed on each lot.
WB: 1:1000. Researchers should empirically determine the suitability of the RARB rarb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The RARB rarb product has the following accession number(s) (GI #14916494) (NCBI Accession #NP_000956.2) (Uniprot Accession #P10826). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Retinoic Acid Receptor, beta-Isotype with the following immunoassay(s):
Affinity purified mouse monoclonal antibody.
Antigen: Peptide corresponding to amino acids from N-terminal region of human retinoic acid receptor, beta-isotype. The antigen is identical in both beta1 and beta2 isoforms.
Immunogen Information: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH
Immunogen Species: Human. Reactivity Assumed Based on 100% Sequence Homology: Canine, guinea pig, mouse and non-human primate
Species Reactivity Note: The antibody has been directly tested for reactivity in Western blots in human and rat tissues. It is anticipated that the antibody will also work with canine, guinea pig, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Biological Significance: Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X receptors (RXRs) family (RXRalpha, beta and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing RARB are readily searchable from our website. Different antibodies against the same target such as RARB may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.