anti-PGR antibody product blogThe PGR pgr (Catalog #MBS245536) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal (IgG1,k) to Human PGR/PR/Progesterone Receptor reacts with Human, Monkey, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PGR/PR/Progesterone Receptor can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP).
IF, IHC-P (1:50), IP, WB (1 - 2 ug/ml)
Usage: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, and Sedimentation in sucrose gradients. Immunoprecipitation (NATIVE ONLY): 2 ug/mg protein lysate Using Protein G. Western Blot: 1-2 ug/ml for 2 hrs at RT. Positive control: T.. Researchers should empirically determine the suitability of the PGR pgr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PGR pgr product has the following accession number(s) (GI #110611914) (NCBI Accession #NP_000917.3) (Uniprot Accession #P06401). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Monoclonal (IgG1,k) to Human PGR/PR/Progesterone Receptor with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-PGR / Progesterone Receptor antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)
The progesterone receptor, a NR3 Steroid Receptor, is induced in granulosa cells of preovulatory follicles in response to surges in luteinizing hormone. It is essential for ovulation and egg implantation. A decrease in expression of endometrial progesterone receptor results in infertility in women. This receptor mediates the progesterone-induced transcription of proteases including ADAMTS1 and cathepsin L.
Target Species: Human
Immunogen Description: Synthetic peptide from human PGR / Progesterone Receptor. Immunogen Type: Synthetic peptide
Immunogen: PGR/PR/Progesterone Receptor antibody was raised against synthetic peptide from human PGR / Progesterone Receptor. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PGR are readily searchable from our website. Different antibodies against the same target such as PGR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. PGR also interacts with the following gene(s): CCND1, ERBB2, KLF9, NCOA1, NCOA3, NCOR2, SP1, SRC.