anti-PF4V1 antibody product blogThe PF4V1 pf4v1 (Catalog #MBS520501) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human Platelet Factor 4, Purified (Clone: RTO) (Mouse IgG2b) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Platelet Factor 4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
This antibody is suitable for use in ELISA.
ELISA: Use at a concentration of 0.016ug/ml. Researchers should empirically determine the suitability of the PF4V1 pf4v1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PF4V1 pf4v1 product has the following accession number(s) (GI #292390) (NCBI Accession #AAA60067.1) (Uniprot Accession #P10720). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Platelet factor IV is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity. (clone RTO) is seen to bind free PF4 in the absence of any bound heparin. This is unlike (clone KKO), which binds PF4/heparin complexes to a similar degree as auto-antibodies found in individuals with Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT).
Immunogen: Human Factor IV purified from the supernatant of thrombin activated platelets. Presentation: Purified IgG buffered in PBS and 0.02% NaN3. (Purified from ascitic fluid via Protein G Chromatography). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PF4V1 are readily searchable from our website. Different antibodies against the same target such as PF4V1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adenocarcinoma, Carcinoma, Coronary Thrombosis, Heart Diseases, Inflammation, Liver Neoplasms, Necrosis, Neoplasms, Experimental, Thrombophilia, Vascular Diseases are some of the diseases may be linked to Anti-Human Platelet Factor 4, Purified (Clone: RTO) (Mouse IgG2b).