anti-JAG1 antibody product blogThe JAG1 jag1 (Catalog #MBS242046) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal (IgG) to Human JAG1 / Jagged 1 reacts with Human
Predicted Reactivity: Chimpanzee, Mouse, Rat (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. MyBioSource\'s JAG1 / Jagged 1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA).
ELISA (1:2500 - 1:10000), ICC, IF (1:100 - 1:500), IHC-P (5 ug/ml), WB (1:250 - 1:1000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.. Researchers should empirically determine the suitability of the JAG1 jag1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The JAG1 jag1 product has the following accession number(s) (GI #4557679) (NCBI Accession #NP_000205.1) (Uniprot Accession #P78504). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit Polyclonal (IgG) to Human JAG1 / Jagged 1 with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-JAG1 / Jagged 1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophila jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophila jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Target Species: Human
Immunogen Description: Synthetic peptide corresponding to aa 110-125 of human Jagged-1protein. Immunogen Type: Synthetic peptide
Immunogen: JAG1 / Jagged 1 antibody was raised against synthetic peptide corresponding to aa 110-125 of human Jagged-1protein.
Antigen Modification: aa110-125. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing JAG1 are readily searchable from our website. Different antibodies against the same target such as JAG1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.