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anti-ABL1 antibody product blog

Tags: Antibody; anti-ABL1 antibody; ABL1; ABL1-Y204;

     The ABL1 abl1 (Catalog #MBS125425) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-ABL1-Y204 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s ABL1-Y204 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF).
WB: 1:500 - 1:2000
IF: 1:50 - 1:200. Researchers should empirically determine the suitability of the ABL1 abl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The ABL1 abl1 product has the following accession number(s) (GI #85681908) (NCBI Accession #P00519.4) (Uniprot Accession #P00519). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Phospho-ABL1-Y204 Polyclonal Antibody with the following immunoassay(s):
Immunofluorescence (IF) (Immunofluorescence analysis of MCF-7 cells using Phospho-ABL1-Y204 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF) ABL1.

Immunofluorescence (IF) (Immunofluorescence analysis of U2OS cells using Phospho-ABL1-Y204 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF) ABL1.

Immunofluorescence (IF) (Immunofluorescence analysis of U2OS cells using Phospho-ABL1-Y204 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF) ABL1.

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Species: Human
Route: Synthetic Peptide. Immunogen: A phospho specific peptide corresponding to residues surrounding Y204 of human ABL1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ABL1 are readily searchable from our website. Different antibodies against the same target such as ABL1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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