|The ZIC1 zic1 (Catalog #MBS9221377) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The ZIC1 zic1 product has the following accession number(s) (GI #209572702) (NCBI Accession #Q15915.2) (Uniprot Accession #Q15915). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5\'- TGGGTGGTC-3\' (By similarity).
Cellular Location: Nucleus. Cytoplasm. Note: Localizes in the cytoplasm in presence of MDFIC overexpression. Tissue Location: CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined. Abnormalities, Multiple, Ataxia, Brain Diseases, Congenital Abnormalities, Disease Models, Animal, Inflammation, Neoplasms, Experimental, Nervous System Diseases, Nervous System Malformations, Neural Tube Defects are some of the diseases may be linked to ZIC1 Antibody (N-term) Blocking Peptide. The following patways have been known to be associated with this gene.