YES1 blocking peptide product blog
Tags: Blocking Peptide; YES1; YES1 blocking peptide;
The YES1 yes1 (Catalog #MBS9227202) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The YES1 yes1 product has the following accession number(s) (GI #125870) (NCBI Accession #P07947.3) (Uniprot Accession #P07947). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
Cellular Location: Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol Note: Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Tissue Location: Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. Carcinoma, Hepatocellular, Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Liver Diseases, Liver Neoplasms, Lung Diseases, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases, Ovarian Neoplasms are some of the diseases may be linked to YES1 Antibody (N-term) Blocking peptide. Brain, Intestine, Kidney, Liver, Lung, Muscle, Pancreas, Skin, Testis, Vascular tissues are correlated with this protein. YES1 also interacts with the following gene(s): CDC42, EGFR, PIK3CA, PTK2, PXN, RHOA. The following patways have been known to be associated with this gene.