|The XPO5 xpo5 (Catalog #MBS9221393) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The XPO5 xpo5 product has the following accession number(s) (GI #74734245) (NCBI Accession #Q9HAV4.1) (Uniprot Accession #Q9HAV4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.
Cellular Location: Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm. Tissue Location: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Abnormalities, Multiple, Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Models, Animal, Kidney Diseases, Microsatellite Instability, Neoplasms, Experimental, Ovarian Diseases, Ovarian Neoplasms are some of the diseases may be linked to XPO5 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene. Blood, Brain, Embryonic Tissue, Kidney, Liver, Lung, Muscle, Placenta, Stomach, Thyroid tissues are correlated with this protein. XPO5 also interacts with the following gene(s): DGCR8, DICER1, DROSHA, ILF3, NUP153, RAN, TARBP2.