XPC blocking peptide product blog
Tags: Blocking Peptide; XPC; XPC blocking peptide;
The XPC xpc (Catalog #MBS9228587) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The XPC xpc product has the following accession number(s) (GI #224809302) (NCBI Accession #NP_001139241.1) (Uniprot Accession #Q01831). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA- binding activity.
Cellular Location: Nucleus. Cytoplasm. Note: Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions. Bladder, Blood, Bone, Brain, Liver, Lung, Prostate, Skin, Stomach, Testis tissues are correlated with this protein. XPC also interacts with the following gene(s): DDB2, ERCC2, ERCC3, ERCC4, ERCC5, GTF2H1, RAD23A, RAD23B, XPA. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Chromosome Aberrations, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental, Nervous System Diseases, Precancerous Conditions, Urinary Bladder Neoplasms are some of the diseases may be linked to XPC Blocking Peptide(N-term).