|The XAF1 xaf1 (Catalog #MBS9229280) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The XAF1 xaf1 product has the following accession number(s) (GI #74736479) (NCBI Accession #Q6GPH4.1) (Uniprot Accession #Q6GPH4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
Cellular Location: Cytoplasm. Nucleus. Mitochondrion. Note: Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment Isoform 5: Nucleus. Tissue Location: Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level). The following patways have been known to be associated with this gene. Bladder, Blood, Bone, Brain, Kidney, Liver, Lung, Prostate, Stomach, Vascular tissues are correlated with this protein. Adenocarcinoma, Carcinoma, Carcinoma, Hepatocellular, Colonic Neoplasms, Colorectal Neoplasms, Liver Diseases, Liver Neoplasms, Necrosis, Nervous System Diseases, Stomach Neoplasms are some of the diseases may be linked to XAF1 Blocking Peptide (C-term).