WWTR1 blocking peptide product blog
Tags: Blocking Peptide; WWTR1; WWTR1 blocking peptide;
The WWTR1 wwtr1 (Catalog #MBS9229577) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The WWTR1 wwtr1 product has the following accession number(s) (GI #67462080) (NCBI Accession #Q9GZV5.1) (Uniprot Accession #Q9GZV5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Cellular Location: Nucleus. Cytoplasm. Note: Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15. Tissue Location: Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. Bone, Connective Tissue, Kidney, Liver, Lung, Lymph Node, Mouth, Muscle, Thyroid, Vascular tissues are correlated with this protein. Atrophy, Breast Neoplasms, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Congenital Abnormalities, Disease Models, Animal, Kidney Diseases, Liver Diseases, Neoplasm Metastasis, Weight Loss are some of the diseases may be linked to WWTR1 Blocking Peptide (C-term). The following patways have been known to be associated with this gene.