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WDR61 blocking peptide product blog

Posted on 2017-08-07 13:11:43 by mybiosource_staff
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Tags: Blocking Peptide; WDR61; WDR61 blocking peptide;
The WDR61 wdr61 (Catalog #MBS9223325) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.

The WDR61 wdr61 product has the following accession number(s) (GI #74761365) (NCBI Accession #Q9GZS3.1) (Uniprot Accession #Q9GZS3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and \'Ser-2\'- and \'Ser-5\'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 \'Lys-4\' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of \'Lys-120\' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3\' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 \'Lys-4\' (H3K4me3), dimethylation on histone H3 \'Lys-79\' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

WDR61 wdr61

Cellular Location: Nucleus. Cytoplasm. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma are some of the diseases may be linked to WDR61 Antibody (Center) Blocking Peptide. Mammary Gland tissues are correlated with this protein.
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