WASF1 peptide product blog
Tags: Peptide; WASF1; WAVE1 (N-terminal region) Peptide; WASF1 peptide;
The WASF1 wasf1 (Catalog #MBS474070) is a Peptide and is intended for research purposes only. The product is available for immediate purchase.Blocking: 1:1,000
ELISA: 50 ng/well. Researchers should empirically determine the suitability of the WASF1 wasf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The WASF1 wasf1 product has the following accession number(s) (GI #68161504) (NCBI Accession #NP_001020107.1) (Uniprot Accession #Q92558). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Peptide Sequence: A synthetic peptide correspond ing to amino acid residues in the Nterminal half of human WAVE1. This sequence has high homology with similar regions in rat and mouse WAVE1, and has less than 50% homology to similar regions in human WAVE2 and WAVE3.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given peptide. We\'ve tested the WAVE1 (N-terminal region) Peptide with the following immunoassay(s):
Testing Data
The Wiskott-Aldrich syndrome protein (WASP) family is involved in various pathways that regulate actin cytoskeletal organization. This family includes WASP, N-WASP, and three WAVE/SCAR isoforms, WAVE1, 2, and 3. WAVE proteins play key roles in actin-mediated cell events, such as membrane ruffling and lamellipodia formation. WAVEs contain an Nterminal WAVE homology domain, a basic domain, a Proline-rich region, and carboxy terminal verprolin, cofilin, and acidic (VCA) region. WAVEs are thought to act downstream of the Rac GTPase, connecting Rac activation to induction of Arp 2/3-mediated actin polymerization. Regulation of WAVE activity can occur through tyrosine phosphorylation. Src phosphorylation of WAVE1 at Tyr-125 enhances binding to the Arp2/3 complex, and is required for WAVE inhibition of Arp2/3-mediated stress fiber formation. By contrast, WAVE2 phosphorylation of Tyr-150 by Abl may enhance Arp2/3 complex actin nucleation and microspike formation in fibroblasts. Thus, site-specific tyrosine phosphorylation may be important for controlling specific activities of WAVE proteins.
Blood Coagulation Disorders, Melanoma, Experimental, Muscular Diseases, Neoplasms, Neurodegenerative Diseases are some of the diseases may be linked to WAVE1 (N-terminal region) Peptide. The following patways have been known to be associated with this gene. WASF1 also interacts with the following gene(s): ABI1, ACTR2, CDC42, CDK5, PFN1, RAC1. Blood, Bone, Brain, Intestine, Kidney, Lung, Muscle, Nerve, Skin, Stomach tissues are correlated with this protein.