VEGF C recombinant protein product blog
Tags: Recombinant Protein; VEGF C; VEGF C recombinant protein;
The VEGF C vegfc (Catalog #MBS539349) is a Recombinant Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s VEGF C can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the VEGF C vegfc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The VEGF C vegfc product has the following accession number(s) (GI #4885653) (NCBI Accession #NP_005420.1) (Uniprot Accession #P49767). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Region of VEGF C protein correspond ing to amino acids MAHYNTEILK SIDNEWRKTQ CMPREVCIDV GKEFGVATNT FFKPPCVSVY RCGGCCNSEG LQCMNTSTSY LSKTLFEITV PLSQGPKPVT ISFANHTSCR CMSKLDVYRQ VHSIIRR.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including VEGF C are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System: HEK cells. VEGF C also interacts with the following gene(s): ALB, FLT1, FLT4, IGF1R, IGF2, KDR, NRP2, VEGFA, VWF. Bladder, Bone, Bone Marrow, Brain, Embryonic Tissue, Kidney, Lung, Placenta, Skin, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Breast Neoplasms, Cardiovascular Diseases, Edema, Hyperplasia, Inflammation, Lung Diseases, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Experimental are some of the diseases may be linked to VEGF C protein.