VCP blocking peptide product blog
Tags: Blocking Peptide; VCP; VCP blocking peptide;
The VCP vcp (Catalog #MBS9226429) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The VCP vcp product has the following accession number(s) (GI #6094447) (NCBI Accession #P55072.4) (Uniprot Accession #P55072). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation.
Cellular Location: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note: Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients. Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replication forks via interaction with SPRTN. Blood, Bone, Brain, Heart, Liver, Lung, Muscle, Nerve, Thyroid, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. VCP also interacts with the following gene(s): AMFR, ATXN3, DERL1, FAF1, NPLOC4, NSFL1C, SYVN1, UBE4B, UFD1L. Adenocarcinoma, Atrophy, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia, Inflammation, Liver Diseases, Lung Neoplasms, Necrosis are some of the diseases may be linked to VCP Antibody (C-term) Blocking Peptide.