VAV3 blocking peptide product blog
Tags: Blocking Peptide; VAV3; VAV3 blocking peptide;
The VAV3 vav3 (Catalog #MBS9230227) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The VAV3 vav3 product has the following accession number(s) (GI #12643372) (NCBI Accession #Q9UKW4.1) (Uniprot Accession #Q9UKW4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)- mediated adhesion. Does not affect integrin beta-1 (ITGB1)- mediated adhesion (By similarity).
Tissue Location: Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. VAV3 also interacts with the following gene(s): CDC42, LCP2, PLCG1, RAC1, RHOA, RHOG, SHC1, SYK. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Cell Transformation, Neoplastic, Hypertension, Inflammation, Lung Diseases, Lung Neoplasms, Neoplasms, Experimental, Prostatic Neoplasms are some of the diseases may be linked to VAV3 Blocking Peptide (C-term). Brain, Eye, Heart, Intestine, Kidney, Liver, Lung, Lymph Node, Muscle, Prostate tissues are correlated with this protein.