ULK1 blocking peptide product blog
Tags: Blocking Peptide; ULK1; ULK1 blocking peptide; ULK1 (S556);
The ULK1 ulk1 (Catalog #MBS9225330) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The ULK1 ulk1 product has the following accession number(s) (GI #317373288) (NCBI Accession #O75385.2) (Uniprot Accession #O75385). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Cellular Location: Cytoplasm, cytosol. Preautophagosomal structure. Note: Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. Tissue Location: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung. The following patways have been known to be associated with this gene. Blood, Brain, Embryonic Tissue, Heart, Kidney, Lung, Muscle, Nerve, Prostate, Thyroid tissues are correlated with this protein. Breast Neoplasms, Carcinoma, Hepatocellular, Disease Models, Animal, Heart Diseases, Inflammation, Kidney Diseases, Liver Diseases, Liver Neoplasms, Necrosis, Nervous System Diseases are some of the diseases may be linked to Phospho-ULK1(S556) Antibody Blocking peptide. ULK1 also interacts with the following gene(s): AMBRA1, ATG13, ATG9A, GABARAP, GABARAPL1, GABARAPL2, MTOR, RB1CC1, RPTOR.