UIMC1 blocking peptide product blog
Tags: UIMC1; Blocking Peptide; UIMC1 blocking peptide;
The UIMC1 uimc1 (Catalog #MBS9229239) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The UIMC1 uimc1 product has the following accession number(s) (GI #60390957) (NCBI Accession #Q96RL1.2) (Uniprot Accession #Q96RL1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Ubiquitin-binding protein that specifically recognizes and binds \'Lys-63\'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding \'Lys-63\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \'Lys-63\'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than \'Lys-63\'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48\'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Cellular Location: Nucleus. Note: Localizes at sites of DNA damage at double-strand breaks (DSBs). Tissue Location: Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis. UIMC1 also interacts with the following gene(s): BRCA1, FAM175A, RNF8. Blood, Testis tissues are correlated with this protein. Cardiovascular Diseases are some of the diseases may be linked to UIMC1 Blocking Peptide (C-term). The following patways have been known to be associated with this gene.