|The Uhrf2 uhrf2 (Catalog #MBS9230003) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The Uhrf2 uhrf2 product has the following accession number(s) (GI #67462063) (NCBI Accession #Q7TMI3.1) (Uniprot Accession #Q7TMI3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells.
Cellular Location: Nucleus. Note: Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3. Brain Diseases, Breast Neoplasms, Cell Transformation, Neoplastic, Liver Diseases, Nervous System Diseases are some of the diseases may be linked to Uhrf2 Blocking Peptide (Center). Blood, Brain, Embryonic Tissue, Lung tissues are correlated with this protein. Uhrf2 also interacts with the following gene(s): Cdk2, Dnmt1, Dnmt3a, Dnmt3b, Pcnp.