|The TSC2 tsc2 (Catalog #MBS9225150) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The TSC2 tsc2 product has the following accession number(s) (GI #269849475) (NCBI Accession #P49815.2) (Uniprot Accession #P49815). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
Cellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Note: At steady state found in association with membranes. Tissue Location: Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta. Blood, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Muscle, Nerve, Skin tissues are correlated with this protein. TSC2 also interacts with the following gene(s): AKT1, GSK3B, MTOR, PRKAA1, RHEB, RPS6KA1, TSC1, UBC, YWHAB. Brain Diseases, Epilepsy, Kidney Diseases, Kidney Neoplasms, Lung Neoplasms, Lymphangioleiomyomatosis, Neoplasms, Experimental, Seizures, Tuberous Sclerosis, Tuberous Sclerosis 2 are some of the diseases may be linked to Phospho-TSC2(T1462) Antibody Blocking peptide. The following patways have been known to be associated with this gene.