TRIM25 blocking peptide product blog
Tags: TRIM25; Blocking Peptide; TRIM25 blocking peptide;
The TRIM25 trim25 (Catalog #MBS9222058) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The TRIM25 trim25 product has the following accession number(s) (GI #313104033) (NCBI Accession #Q14258.2) (Uniprot Accession #Q14258). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates \'Lys-63\'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.
Cellular Location: Cytoplasm. Note: Colocalized with DDX58 at cytoplasmic perinuclear bodies. Tissue Location: Ubiquitous.. Brain Diseases, Cardiovascular Diseases, Inflammation, Liver Diseases, Necrosis, Neoplasms, Experimental, Nervous System Diseases, Ovarian Diseases, Prostatic Diseases, Prostatic Neoplasms are some of the diseases may be linked to TRIM25 Antibody (Center) Blocking Peptide. Blood, Brain, Intestine, Lung, Lymph, Lymph Node, Mammary Gland, Ovary, Spleen, Uterus tissues are correlated with this protein. The following patways have been known to be associated with this gene.