TPO recombinant protein product blog
Tags: TPO; Recombinant Protein; TPO recombinant protein; Thyroid Peroxidase;
The TPO tpo (Catalog #MBS537916) is a Recombinant Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Thyroid Peroxidase can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the TPO tpo for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The TPO tpo product has the following accession number(s) (GI #5705932) (NCBI Accession #AAB23677.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including Thyroid Peroxidase are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: Thyroid Peroxidase (TPO) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. Its identity with the formerly so-called `microsomal antigen` has been shown several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx. 100 kDa molecular weight. The hemoprotein TPO plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin (TG) to form precursors of the thyroid hormones T4 and T3. Expression System: Sf-9 insect cells. Blood Coagulation Disorders, Brain Diseases, Central Nervous System Diseases, Congenital Hypothyroidism, Goiter, Hepatitis, Liver Diseases, Mental Disorders, Thyroid Diseases, Thyroid Neoplasms are some of the diseases may be linked to Thyroid Peroxidase protein. Adipose Tissue, Blood, Brain, Connective Tissue, Heart, Intestine, Muscle, Spleen, Testis, Thyroid tissues are correlated with this protein. The following patways have been known to be associated with this gene.