TLR3 positive control product blog
Tags: TLR3; Positive Control; TLR3 positive control;
The TLR3 tlr3 (Catalog #MBS543322) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s TLR3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western Blot: 1:500. Researchers should empirically determine the suitability of the TLR3 tlr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TLR3 tlr3 product has the following accession number(s) (GI #64653340) (NCBI Accession #AAH96333.1) (Uniprot Accession #O15455). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Western Blot Positive Control Toll-like receptor 3
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection.
Immunogen: Purified Protein
Expression: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. Molecular Function: Receptor, double-stranded RNA binding, transmembrane signaling receptor activity
Structure: Monomer and homodimer; dimerization is triggered by ligand-binding, the signaling unit is composed of one ds-RNA of around 40 bp and two TLR3 molecules, and lateral clustering of signaling units along the length of the ds-RNA ligand is required for TLR3 signal transduction. Interacts (via transmembrane domain) with UNC93B1; the interaction is required for transport from the ER to the endosomes.
Subcellular Location: Endoplasmic Reticulum membrane; Single-pass type I membrane protein, Endosome membrane. Adenocarcinoma, Asthma, Carcinoma, Hepatocellular, Encephalitis, Herpes Simplex, Heart Diseases, Inflammation, Kidney Diseases, Lung Diseases, Necrosis, Vascular Diseases are some of the diseases may be linked to TLR3 Positive Control. The following patways have been known to be associated with this gene. Bone, Brain, Eye, Intestine, Kidney, Liver, Lung, Muscle, Skin, Spleen tissues are correlated with this protein. TLR3 also interacts with the following gene(s): DDX58, MYD88, NFKB1, RIPK1, TAB2, TICAM1, TRAF6, UNC93B1.