|The TJP1 tjp1 (Catalog #MBS9225366) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The TJP1 tjp1 product has the following accession number(s) (GI #85700443) (NCBI Accession #Q07157.3) (Uniprot Accession #Q07157). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
Cellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction Cell junction, gap junction. Note: Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells. Tissue Location: The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. Brain Diseases, Cardiovascular Diseases, Disease Models, Animal, Edema, Inflammation, Kidney Diseases, Liver Diseases, Lung Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to ZO1 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene. TJP1 also interacts with the following gene(s): CDH1, CGN, CLDN2, CSDA, CTTN, GJA1, KIRREL, MLLT4, OCLN, TJP2. Blood, Brain, Embryonic Tissue, Eye, Intestine, Kidney, Liver, Lung, Muscle, Vascular tissues are correlated with this protein.