SUFU blocking peptide product blog
Tags: Blocking Peptide; SuFu; SUFU blocking peptide;
The SUFU sufu (Catalog #MBS9230257) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The SUFU sufu product has the following accession number(s) (GI #62511179) (NCBI Accession #Q9UMX1.2) (Uniprot Accession #Q9UMX1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU- GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).
Cellular Location: Cytoplasm. Nucleus. Tissue Location: Ubiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis. Isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney. Blood, Bone, Brain, Embryonic Tissue, Eye, Heart, Lung, Muscle, Prostate, Skin tissues are correlated with this protein. SUFU also interacts with the following gene(s): GLI1, GLI2, GLI3, LGALS3, PIAS1, PTCH1, PTCH2, SAP18, SMO, STK36. Adenocarcinoma, Carcinoma, Basal Cell, Cell Transformation, Neoplastic, Heart Diseases, Hyperplasia, Kidney Diseases, Medulloblastoma, Neoplasms, Experimental, Ovarian Neoplasms, Weight Loss are some of the diseases may be linked to SUFU Blocking Peptide (C-term). The following patways have been known to be associated with this gene.