SU11274 kinase inhibitor product blog
Tags: Kinase Inhibitor; SU11274; SU11274 kinase inhibitor;
The SU11274 n/a (Catalog #MBS8506331) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given inhibitor. We\'ve tested the SU11274 with the following immunoassay(s):
Testing Data
SU11274 is a highly specific inhibitor of c-Met, with in vitro IC50 for the Met enzyme at 0.012 mumol/L. The inhibitor did not affect other tyrosine kinase oncoproteins, including BCR-ABL, TEL-JAK2, TEL-PDGF_R, or TEL-ABL. Inhibition of the Met kinase activity by SU11274 led to time-and dose-dependent reduced cell growth. [1] Further study shows SU11274 belongs to a class of small molecule RTK inhibitors that exert their activity by competing for the Mg-ATP complex binding pocket, which results in inhibition of kinase activity and subsequent downstream signaling. [2].
Solubility: DMSO >=92mg/mL - Water <1mg/mL - Ethanol >=2mg/mL. Formula: C28H30CIN5O4S
CAS Number: 658084-23-2.