STX17 blocking peptide product blog
Tags: Blocking Peptide; STX17; STX17 blocking peptide;
The STX17 stx17 (Catalog #MBS9220041) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The STX17 stx17 product has the following accession number(s) (GI #212286190) (NCBI Accession #P56962.2) (Uniprot Accession #P56962). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).
Cellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytosol. Note: Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria according to PubMed:23217709. A significant amount is also present in the cytosol. The following patways have been known to be associated with this gene. Blood, Brain, Embryonic Tissue, Eye, Liver, Pancreas, Skin, Thyroid, Vascular tissues are correlated with this protein. Alopecia Areata, Carcinoma, Hepatocellular, Liver Neoplasms, Melanoma, Necrosis, Skin Neoplasms are some of the diseases may be linked to STX17 Antibody (N-term) Blocking peptide.