SRGAP2 blocking peptide product blog
Tags: Blocking Peptide; SRGAP2; SRGAP2 blocking peptide;
The SRGAP2 srgap2 (Catalog #MBS9230236) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The SRGAP2 srgap2 product has the following accession number(s) (GI #48427907) (NCBI Accession #O75044.2) (Uniprot Accession #O75044). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
Cellular Location: Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, postsynaptic cell membrane. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome Nucleus. Cytoplasm. Note: Recruited to actin-rich phagosomes during phagocytosis. Translocates from nucleus to cytoplasm during development. The following patways have been known to be associated with this gene. SRGAP2 also interacts with the following gene(s): CDC42, FMNL1, RAC1, RAC2, RHOA, RHOQ, ROBO1. Breast Neoplasms, Disease Models, Animal, Inflammation, Melanoma, Nervous System Diseases are some of the diseases may be linked to SRGAP2 Blocking Peptide (C-term). Blood, Brain, Eye, Kidney, Lung, Nerve, Placenta, Prostate, Spleen, Uterus tissues are correlated with this protein.