Sqstm1 blocking peptide product blog
Tags: SQSTM1; Blocking Peptide; SQSTM1 blocking peptide; Sqstm1 (S351);
The Sqstm1 sqstm1 (Catalog #MBS9229323) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Sqstm1 sqstm1 product has the following accession number(s) (GI #77416573) (NCBI Accession #Q64337.1) (Uniprot Accession #Q64337). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.
Cellular Location: Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Lysosome. Cytoplasmic vesicle, autophagosome. Cytoplasm, P-body. Note: Sarcomere. In cardiac muscles localizes to the sarcomeric band. May also localize to the hepatocellular carcinoma. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates (By similarity) Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity). Tissue Location: Widely expressed. Adenocarcinoma, Amyotrophic Lateral Sclerosis, Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Inflammation, Liver Diseases, Necrosis, Nervous System Diseases, Osteitis Deformans are some of the diseases may be linked to Sqstm1(S351) Blocking Peptide. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Spinal Cord tissues are correlated with this protein.