SQSTM 1 blocking peptide product blog
Tags: Blocking Peptide; Sequestosome-1; SQSTM 1 blocking peptide; SQSTM 1;
The SQSTM 1 sqstm1 (Catalog #MBS5400655) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Sequestosome-1 can be used in a range of immunoassay formats including, but not limited to, Immunodepletion, Immunocompetition.Immunocompetition: 1:500. Researchers should empirically determine the suitability of the SQSTM 1 sqstm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SQSTM 1 sqstm1 product has the following accession number(s) (GI #214830438) (NCBI Accession #NP_001135770.1) (Uniprot Accession #Q13501). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Overview: Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD. May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
Peptide Description: Synthetic peptide taken within amino acid region 400-440 on human Sequestosome-1 protein
Structure: Homooligomer or heterooligomer; may form homotypic arrays. Dimerization interferes with ubiquitin binding
Expression: Ubiquitously expressed.
Molecular Function: identical protein binding; protein kinase binding; protein kinase C binding; protein serine/threonine kinase activity; receptor tyrosine kinase binding; SH2 domain binding; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding
Subcellular Location: Cytoplasm; Late Endosome; Lysosome; Cytoplasmic Vesicle; Autophagosome; Nucleus; Endoplasmic Reticulum; Cytoplasm; P-body. SQSTM 1 also interacts with the following gene(s): KEAP1, MAP1LC3A, NBR1, NTRK1, TRAF6, UBB. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Nerve, Vascular tissues are correlated with this protein. Amyotrophic Lateral Sclerosis, Breast Neoplasms, Carcinoma, Hepatocellular, Cardiovascular Diseases, Disease Models, Animal, Inflammation, Liver Diseases, Necrosis, Nerve Degeneration, Osteitis Deformans are some of the diseases may be linked to Sequestosome-1 Blocking Peptide.