SPDL1 blocking peptide product blog
Tags: Blocking Peptide; CCDC99; SPDL1; SPDL1 blocking peptide;
The SPDL1 spdl1 (Catalog #MBS9219958) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The SPDL1 spdl1 product has the following accession number(s) (GI #296452913) (NCBI Accession #Q96EA4.2) (Uniprot Accession #Q96EA4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
Cellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole Note: Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex. Brain tissues are correlated with this protein. The following patways have been known to be associated with this gene.