Sorafenib, p-Toluenesulfonate Salt inhibitor product blog
Tags: Inhibitor; Sorafenib, p-Toluenesulfonate Salt; Sorafenib, p-Toluenesulfonate Salt inhibitor;
The Sorafenib, p-Toluenesulfonate Salt n/a (Catalog #MBS655375) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given inhibitor. We\'ve tested the Sorafenib, p-Toluenesulfonate Salt (4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide Tosylate, Sorafenib Tosylate, Bay 43-9006, Nexavar, DB00398, NSC-724772) with the following immunoassay(s):
Testing Data (4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide Tosylate, Sorafenib Tosylate, Bay 43-9006, Nexavar, DB00398, NSC-724772)
Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-b and their associated signaling cascades. Although sorafenib was initially developed as a Raf kinase inhibitor (IC50=6nM), it has since been shown to have activity against many receptor tyrosine kinases involved in tumorigenesis and angiogenesis including FGFR-1, wt BRAF and V599E mutant BRAF, as well as members of the so-called "split kinase" family: VEGFR-2, VEGFR-3, PDGFR-b, c-KIT, and Flt3. However, sorafenib is not active against erbB1, erbB2, ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-MET, c-yes, PKB, PKA, cdk1/cyclinB, PKC, and pim-1. In cellular mechanistic assays, sorafenib decreased basal phosphorylation of the ERK pathway in melanoma, breast, colon, and pancreatic tumor cell lines.
CAS Number: 475207-59-1
Molecular Formula: C21H16ClF3N4O3• C7H8O3S
Grade: Highly Purified
Elemental Analysis: Actual: %C=52.86 %H=3.93 %Cl=5.53 %F=8.85 %N=8.90 %S4.86. Solubility: Soluble in DMSO at 200mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.