SMARCD1 blocking peptide product blog
Tags: Blocking Peptide; SMARCD1; SMARCD1 blocking peptide;
The SMARCD1 smarcd1 (Catalog #MBS9221499) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The SMARCD1 smarcd1 product has the following accession number(s) (GI #238054318) (NCBI Accession #Q96GM5.2) (Uniprot Accession #Q96GM5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancer Vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene.
Cellular Location: Nucleus. Tissue Location: Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta. Abnormalities, Multiple, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Disease Models, Animal, Dyslipidemias, Fatty Liver, Genital Diseases, Female, Male Urogenital Diseases, Neoplasms, Experimental, Prostatic Diseases are some of the diseases may be linked to SMARCD1 Antibody (C-term) Blocking Peptide. Ascites, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Stomach tissues are correlated with this protein. SMARCD1 also interacts with the following gene(s): ACTL6A, ARID1B, SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCE1. The following patways have been known to be associated with this gene.