|The SMAD4 smad4 (Catalog #MBS9227223) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The SMAD4 smad4 product has the following accession number(s) (GI #13959561) (NCBI Accession #Q13485.1) (Uniprot Accession #Q13485). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5\'-GTCT/AGAC-3\') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Cellular Location: Cytoplasm. Nucleus. Note: Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R- SMAD. PDPK1 prevents its nuclear translocation in response to TGF- beta. SMAD4 also interacts with the following gene(s): BMP2, EP300, PIAS4, SKI, SKIL, SMAD1, SMAD2, SMAD3, TRIM33, UBC. Cardiovascular Diseases, Cell Transformation, Neoplastic, Colorectal Neoplasms, Disease Models, Animal, Fibrosis, Inflammation, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental are some of the diseases may be linked to SMAD4 Antibody (C-term) Blocking Peptide. Blood, Bone, Brain, Embryonic Tissue, Kidney, Liver, Lung, Muscle, Pancreas, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.