Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Blog  rightarrow SMAD4 blocking peptide  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
separator
 • SLC1A4 sirna blog
 • Sodium [(2, 3-dihydro-1, 5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate inhibitor blog
 • uCHL3 recombinant protein blog
 • CALCOCO2 sirna blog
 • POLD4 sirna blog
 • anti-CD19 antibody blog
 • mmu-miR-301b-5p mirna blog
 • NMRK1 sirna blog
 • ANXA7 blocking peptide blog
 • G3BP1 blocking peptide blog
 • anti-Mycoplasma gallisepticum antibody blog
 • FXa elisa kit blog
 • NADPH elisa kit blog
 • anti-Streptococcus Group A antibody blog
 • PVRL2 elisa kit blog
 • NENF peptide blog
 • Beta-Casomorphin-5 biologically active peptide blog
 • SOX2 recombinant protein blog
 • anti-IgY (IgG) (Fc) antibody blog
 • GALNT13 sirna blog
separator
Blog Categories separator
separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
separator
Our Best Sellers moreseparator
separator
 • BLMH Antibody
 • Cadherin-5 (CDH5) Recombinant Protein
 • A Disintegrin And Metalloprotease 20 (ADAM20) Antibody
 • IL-10 Recombinant Protein
 • Keap1 Antibody
 • Prolactin (PRL) Antibody
 • CD14 Antibody
 • IgG1 Antibody
 • Kremen protein 1 (KREMEN1) ELISA Kit
 • CX43 ELISA Kit
 • MITOCHONDRIAL MEMBRANE POTENTIAL MitoPT TMRM KIT Kit
 • Pneumolysin (ply) Antibody
 • Carcinoembryonic Antigen (CEACAM5) Protein
 • MLK1-2 Antibody
 downarrow more ...
separator

SMAD4 blocking peptide product blog

separator
Posted on 2017-12-09 22:31:09 by mybiosource_staff
Share it on ...     
separator
separator
Tags: SMAD4; Blocking Peptide; SMAD4 blocking peptide;
separator
The SMAD4 smad4 (Catalog #MBS9227223) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.

The SMAD4 smad4 product has the following accession number(s) (GI #13959561) (NCBI Accession #Q13485.1) (Uniprot Accession #Q13485). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5\'-GTCT/AGAC-3\') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

SMAD4 smad4

Cellular Location: Cytoplasm. Nucleus. Note: Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R- SMAD. PDPK1 prevents its nuclear translocation in response to TGF- beta. SMAD4 also interacts with the following gene(s): BMP2, EP300, PIAS4, SKI, SKIL, SMAD1, SMAD2, SMAD3, TRIM33, UBC. Cardiovascular Diseases, Cell Transformation, Neoplastic, Colorectal Neoplasms, Disease Models, Animal, Fibrosis, Inflammation, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental are some of the diseases may be linked to SMAD4 Antibody (C-term) Blocking Peptide. Blood, Bone, Brain, Embryonic Tissue, Kidney, Liver, Lung, Muscle, Pancreas, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions