SMAD3 blocking peptide product blog
Tags: Smad3; Blocking Peptide; SMAD3 blocking peptide;
The SMAD3 smad3 (Catalog #MBS9229783) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The SMAD3 smad3 product has the following accession number(s) (GI #51338669) (NCBI Accession #P84022.1) (Uniprot Accession #P84022). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Cellular Location: Cytoplasm. Nucleus. Note: Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta. SMAD3 also interacts with the following gene(s): CREBBP, EP300, JUN, SKI, SKIL, SMAD4, SP1, TGFBR1, UBC, ZFYVE9. The following patways have been known to be associated with this gene. Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Fibrosis, Heart Diseases, Inflammation, Kidney Diseases, Liver Cirrhosis, Liver Diseases, Necrosis are some of the diseases may be linked to SMAD3 Blocking Peptide (Center). Blood, Bone, Connective Tissue, Heart, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein.