SIRT6 blocking peptide product blog
Tags: SIRT6; Blocking Peptide; SIRT6 blocking peptide;
The SIRT6 sirt6 (Catalog #MBS9225983) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The SIRT6 sirt6 product has the following accession number(s) (GI #38258612) (NCBI Accession #Q8N6T7.2) (Uniprot Accession #Q8N6T7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Cellular Location: Nucleus, nucleoplasm. Note: Predominantly nuclear Associated with telomeric heterochromatin regions. SIRT6 also interacts with the following gene(s): BIRC5, FOXO1, FOXO3, G3BP1, HDAC9, JUN, PARP1, RBBP8. The following patways have been known to be associated with this gene. Atherosclerosis, Carcinoma, Hepatocellular, Cardiomegaly, Cardiovascular Diseases, Fatty Liver, Hypertrophy, Inflammation, Liver Diseases, Liver Neoplasms, Necrosis are some of the diseases may be linked to SIRT6 Antibody (C-term) Blocking Peptide. Blood, Bone, Brain, Connective Tissue, Heart, Liver, Lung, Muscle, Ovary, Skin tissues are correlated with this protein.