SIGLEC7 blocking peptide product blog
Tags: Blocking Peptide; SIGLEC7; SIGLEC7 (D-siglec); SIGLEC7 blocking peptide;
The SIGLEC7 siglec7 (Catalog #MBS9221562) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The SIGLEC7 siglec7 product has the following accession number(s) (GI #25009269) (NCBI Accession #Q9Y286.1) (Uniprot Accession #Q9Y286). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Cellular Location: Membrane; Single-pass type I membrane protein. Tissue Location: Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes. Adrenal Gland, Blood, Eye, Liver, Spleen tissues are correlated with this protein. Cell Transformation, Neoplastic, Colorectal Neoplasms, Immune System Diseases, Inflammation, Kidney Diseases, Lung Neoplasms, Necrosis, Nervous System Diseases, Peripheral Nervous System Diseases are some of the diseases may be linked to SIGLEC7 (D-siglec) Antibody (N-term) Blocking peptide. The following patways have been known to be associated with this gene.