Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource  rightarrow Blog  rightarrow SH2B1 blocking peptide  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
 • babo positive control blog
 • NSE elisa kit blog
 • DIRAS1 shrna blog
 • ATCAY shrna blog
 • anti-SLITRK3 antibody blog
 • PCED1A sirna blog
 • CD14 peptide blog
 • MSH elisa kit blog
 • SENP3 blocking peptide blog
 • ZNF575 sirna blog
 • anti-CD11b/c antibody blog
 • anti-TEP1 antibody blog
 • ZNF532 sirna blog
 • ITGb3 recombinant protein blog
 • CRAMP1L sirna blog
 • beta2M recombinant protein blog
 • GLP-2 peptide blog
 • IgG4 elisa kit blog
 • Plectasin biologically active peptide blog
 • anti-ACAP3 antibody blog
Blog Categories separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
Our Best Sellers moreseparator
 • CFTR Antibody
 • Monocyte Chemoattractant Protein-induced Protein 1 (MCPIP) ELISA Kit
 • 14-3-3 Zeta (1433Z) ELISA Kit
 • Creatine Kinase MB (CK-MB) Type II, Recombinant Recombinant Protein
 • 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) ELISA Kit
 • FOXP2 Antibody
 • H5 (A-Anhui-1-2005)(H5N1) Antibody
 • Activation-induced cytidine deaminase (AICDA) ELISA Kit
 • Calpain-1 catalytic subunit (Capn1) Recombinant Protein
 • Red Blood Cells Animal Serum
 • Sonic HedgeHog (SHH) Recombinant Protein
 • Dengue NS1 Antibody
 • Prolactin (PRL) ELISA Kit
 • KIF26B Antibody
 downarrow more ...

SH2B1 blocking peptide product blog

Posted on 2016-11-10 12:25:51 by mybiosource_staff
Share it on ...     
Tags: Blocking Peptide; SH2B1; SH2B1 blocking peptide;
The SH2B1 sh2b1 (Catalog #MBS9221349) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.

The SH2B1 sh2b1 product has the following accession number(s) (GI #313104186) (NCBI Accession #Q9NRF2.3) (Uniprot Accession #Q9NRF2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated (\'Tyr-813\') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on \'Ser-473\' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity).

SH2B1 sh2b1

Cellular Location: Cytoplasm. Membrane. Nucleus. Note: Shuttles between the nucleus and the cytoplasm. Tissue Location: Widely expressed with highest levels in skeletal muscle and ovary. Blood, Brain, Connective Tissue, Heart, Liver, Lung, Lymph Node, Muscle, Nerve, Pancreas tissues are correlated with this protein. SH2B1 also interacts with the following gene(s): AKT1, GRB2, IRS1, JAK2, JAK3, NTRK2, SH2B3. Cardiovascular Diseases, Diabetes Mellitus, Type 2, Disease Models, Animal, Heart Diseases, Hyperglycemia, Hypertension, Immune System Diseases, Nervous System Diseases, Obesity, Weight Loss are some of the diseases may be linked to SH2B1 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions