|The SH2B1 sh2b1 (Catalog #MBS9221349) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The SH2B1 sh2b1 product has the following accession number(s) (GI #313104186) (NCBI Accession #Q9NRF2.3) (Uniprot Accession #Q9NRF2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated (\'Tyr-813\') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on \'Ser-473\' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity).
Cellular Location: Cytoplasm. Membrane. Nucleus. Note: Shuttles between the nucleus and the cytoplasm. Tissue Location: Widely expressed with highest levels in skeletal muscle and ovary. Blood, Brain, Connective Tissue, Heart, Liver, Lung, Lymph Node, Muscle, Nerve, Pancreas tissues are correlated with this protein. SH2B1 also interacts with the following gene(s): AKT1, GRB2, IRS1, JAK2, JAK3, NTRK2, SH2B3. Cardiovascular Diseases, Diabetes Mellitus, Type 2, Disease Models, Animal, Heart Diseases, Hyperglycemia, Hypertension, Immune System Diseases, Nervous System Diseases, Obesity, Weight Loss are some of the diseases may be linked to SH2B1 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene.