SGK1 peptide product blog
Tags: Peptide; SGK1; SGK1, aa399-412; SGK1 peptide;
The SGK1 sgk1 (Catalog #MBS633715) is a Peptide produced from Synthetic peptide and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s SGK1, aa399-412 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot and Inhibition assay when used with anti-SGK1. Researchers should empirically determine the suitability of the SGK1 sgk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SGK1 sgk1 product has the following accession number(s) (GI #219521880) (NCBI Accession #NP_001137150.1) (Uniprot Accession #O00141). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Synthetic peptide (CGKSPDSVLVTASVK) (linear) corresponding to aa399-412 of human SGK1.
Serum and glucocorticoid-inducible kinases (SGKs) belong to a family of serine/threonine kinases that are regulated at both the transcriptional and posttranslational levels by external stimuli. SGKs are members of the AGC subfamily that includes the PKC isoforms, cyclic-AMP-dependent PKA and p90RSK. There are three isoforms, SGK1, SGK2 and SGK3. The transcriptional regulation of the two closely related isoforms, SGK2 and SGK3, are not well known. They can be activated by phosphorylation. SGK3 has been implicated in the IL-3 mediated survival of hematopoietic cells. SGK1 contains a catalytic domain that is ~45-55% homologous to the catalytic domains of PKA, PKB, PKC-zeta and rat p70S6K/p85 S6K kinases which propagate cell signalling cascades associated with the Positive Control of cell growth, differentiation and cell survival. The availability and function of SGK1 is regulated at three distinct levels of cellular control. First, SGK1 gene expression is strongly stimulated by hormonal and nonhormonal cues. Second, like PKB, SGK1 is phosphorylated and enzymatically activated as a downstream component of the PI 3-kinase signalling cascade that mediates the mitogenic and cell survival responses to many growth factors and insulin. Finally, the subcellular localization of SGK1 is controlled by the cell cycle and exposure to specific hormones and environmental stress stimuli. SGK1 plays an important role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (1-4).
The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Intestine, Kidney, Liver, Lung, Muscle, Vascular tissues are correlated with this protein. Brain Diseases, Carcinoma, Cardiovascular Diseases, Fibrosis, Hypertension, Inflammation, Kidney Diseases, Neoplasms, Nervous System Diseases, Proteinuria are some of the diseases may be linked to SGK1, aa399-412 (Serum and Glucocorticoid-regulated Protein Kinase 1).