SETD8 blocking peptide product blog
Tags: Blocking Peptide; SETD8; SETD8 blocking peptide;
The SETD8 kmt5a (Catalog #MBS9226153) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The SETD8 kmt5a product has the following accession number(s) (GI #25091219) (NCBI Accession #Q9NQR1.3) (Uniprot Accession #Q9NQR1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates \'Lys-20\' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at \'Lys-382\', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
Cellular Location: Nucleus. Chromosome. Note: Specifically localizes to mitotic chromosomes. Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress- dependent manner. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin. Kidney, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene. SETD8 also interacts with the following gene(s): PCNA, SETD8.