SEMA4D blocking peptide product blog
Tags: SEMA4D; Blocking Peptide; SEMA4D blocking peptide;
The SEMA4D sema4d (Catalog #MBS9230016) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The SEMA4D sema4d product has the following accession number(s) (GI #8134701) (NCBI Accession #Q92854.1) (Uniprot Accession #Q92854). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. SEMA4D also interacts with the following gene(s): ARHGAP35, ARHGEF11, ARHGEF12, CD72, MET, PLXNB1, PLXNB2, RHOA, RND1, RRAS. Blood, Bone Marrow, Brain, Embryonic Tissue, Kidney, Lung, Lymph Node, Nerve, Skin, Spinal Cord tissues are correlated with this protein. The following patways have been known to be associated with this gene. Atherosclerosis, Brain Diseases, Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Inflammation, Kidney Diseases, Lung Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to SEMA4D Blocking Peptide (C-term).