|The SDCBP sdcbp (Catalog #MBS9228789) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The SDCBP sdcbp product has the following accession number(s) (GI #56243522) (NCBI Accession #NP_005616.2) (Uniprot Accession #O00560). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Cellular Location: Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Note: Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum Colocalized with actin stress fibers. Also found in the nucleus Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Tissue Location: Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta. The following patways have been known to be associated with this gene. SDCBP also interacts with the following gene(s): CD6, IL5RA, NFASC, SDC1, SDC2, SDC4, SOX4, ULK1. Blood, Brain, Embryonic Tissue, Kidney, Liver, Lung, Lymph, Lymph Node, Nerve, Vascular tissues are correlated with this protein. Brain Diseases, Breast Neoplasms, Carcinoma, Disease Models, Animal, Inflammation, Kidney Diseases, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental are some of the diseases may be linked to SDCBP Blocking Peptide (N-term).