|The SCNN1A scnn1a (Catalog #MBS9227859) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The SCNN1A scnn1a product has the following accession number(s) (GI #585966) (NCBI Accession #P37088.1) (Uniprot Accession #P37088). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Cellular Location: Apical cell membrane; Multi-pass membrane protein. Cell projection, cilium. Note: In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non-ciliated epithelial cells, restricted to apical surfaces. Tissue Location: Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Blood, Brain, Embryonic Tissue, Intestine, Kidney, Liver, Lung, Placenta, Salivary Gland, Thyroid tissues are correlated with this protein. The following patways have been known to be associated with this gene. Bronchiectasis With Or Without Elevated Sweat Chloride 2, Cardiovascular Diseases, Cystic Fibrosis, Disease Models, Animal, Fibrosis, Hypertension, Kidney Diseases, Lung Diseases, Pseudohypoaldosteronism, Vascular Diseases are some of the diseases may be linked to SCNN1A Antibody (Center) Blocking Peptide.