|The SCF kitlg (Catalog #MBS538024) is a Recombinant Protein produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s SCF can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the SCF kitlg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SCF kitlg product has the following accession number(s) (GI #1246100) (NCBI Accession #AAB35922.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Region of SCF protein correspond ing to amino acids MKEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including SCF are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: SCF is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on Mouse cells, while Mouse and rat SCF are fully active on human cells.
Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells is 1 x 10^5 units/mg.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System: E Coli. Anemia, Bone Marrow Diseases, Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Heart Diseases, Inflammation, Myocardial Ischemia, Necrosis, Neoplasms, Germ Cell and Embryonal are some of the diseases may be linked to SCF protein (Mouse). Blood, Bone, Brain, Connective Tissue, Embryonic Tissue, Liver, Lung, Muscle, Nerve, Vascular tissues are correlated with this protein. SCF also interacts with the following gene(s): EPOR, GDF9, GRB2, JAK2, KIT, MATK, MYB, SHC1, STAT3. The following patways have been known to be associated with this gene.