SB590885 kinase inhibitor product blog
Tags: Kinase Inhibitor; SB590885; SB590885 kinase inhibitor;
The SB590885 n/a (Catalog #MBS8506522) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given inhibitor. We\'ve tested the SB590885 with the following immunoassay(s):
Testing Data
SB-590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration, which is distinct from the previously reported mechanism of action of the multi-kinase inhibitor, BAY43-9006. Interestingly, selectivity towards B-Raf was shown as SB-590885 inhibited c-Raf with a Ki app of 1.72 +/-0.65 nM. These results showed that SB-590885 was a more potent inhibitor than the previously described Raf/VEGFR kinase inhibitor BAY 43-9006 (Ki app = 38 nM for mutant B-Raf, 6 nM for c-Raf) and exhibited more selectivity towards B-Raf inhibition. SB-590885 was further profiled against a panel of 48 other human kinases, comprising representatives from all of the main branches of the human kinome. Strikingly, SB-590885 displayed remarkable specificity for B-Raf inhibition, with significant activity measured only against c-Raf and minimal off-target activity.[1][2].
Solubility: Unknown. Formula: C27H27N5O2
CAS Number: 405554-55-4.